STAT5 acetylation

STAT5 acetylation

The cytokine-inducible transcription factors signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) are important for the proper development of multicellular eukaryotes. Disturbed signaling cascades evoking uncontrolled expression of STAT5 target genes are associated with cancer and immunological failure. Here, we summarize how STAT5 acetylation is integrated into posttr...

Acetylation and sumoylation control STAT5 activation antagonistically

STAT5 proteins are activated by tyrosine phosphorylation, but recently further post-translation modifications such as serine/threonine phosphorylation, acetylation at lysine residues or sumoylation in close vicinity of the critical tyrosine residue have been reported. Here, we discuss new findings on impaired STAT5 signaling in lymphocytes isolated from a SUMO-specific protease knockout mouse (...

Acetylation of wood – A review

Wood is a porous three dimensional, hydroscopic, viscoelastic, anisotropic bio-polymer composite composed of an interconnecting matrix of cellulose, hemicelluloses and lignin with minor amounts of inorganic elements and organic extractives. Some, but not all, of the cell wall polymer hydroxyl groups are accessible to moisture and these accessible hydroxyls form hydrogen bonds with water. As the...

JAK2-STAT5 signaling

A recent article published by Britschgi et al. in Cancer Cell, "JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer," describes a positive feedback loop of JAK2/STAT5 activation that drives resistance to PI3K/mTOR inhibition in breast cancer. The authors found that genetic or pharmacological inhibition of JAK...

Constitutive Activation of STAT5 Supersedes